Talk of the Nation

President Obama and his Republican challenger Mitt Romney face off in Denver Wednesday for the first of three presidential debates. The president continues to hold a slight lead in many swing states, but Romney's been able to close the gap in the weeks since the conventions.

Over the last few years, singer-songwriter Mary Chapin Carpenter's life has been drastically transformed. In 2007, she suffered a life-threatening pulmonary embolism, her marriage ended soon after and, in the fall of 2011, her father died.

After those experiences, she tells NPR's Neal Conan, grief became a companion — but also a guide, a presence that dictated her outlook on life. The Grammy-winning artist channeled those emotions into her latest album, Ashes and Roses.

With the presidential election a month away, the Court may soon weigh in on several contentious cases. Los Angeles Times Supreme Court correspondent David Savage talks about the upcoming session and whether the Court can insulate itself from the heat of this political season.

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DAVID GREENE, HOST:

It's Tuesday and it means time to read from your comments.

The Oakland A's are headed to the playoffs for the first time in six years, and Washington's Nationals brought the pennant home for the first time since the Senators did it back in 1933. NPR's Mike Pesca talks about the surprises, the end of the baseball season and the outlook for the playoffs.

Elections in Georgia, Ukraine and Lithuania are being closely watched in the West as a test of whether former Soviet states will shift closer to Russia. Russian president Vladimir Putin, for his part, has made political, economic and security reintegration of former Soviet republics a priority.

Decoding the information in DNA may soon be as routine as checking blood pressure. Recent advances make it possible to spell out a person's complete genetic code in a matter of weeks, for roughly the cost of an MRI. NPR's Rob Stein explains the rewards and risks of complete genome sequencing.

NPR's Ari Shapiro spent a week in one city in a battleground state, Colorado Springs, where campaign spending has tripled since 2008. He discovered how it's changing, and the campaign strategy behind targeting specific ads for specific markets in hopes of winning over undecided voters.

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NEAL CONAN, HOST:

This is TALK OF THE NATION. I'm Neal Conan in Washington. Over 18 months Syria has come unraveled. Infuriated by government brutality and emboldened by the Arab Spring, protestors in provincial cities took to the streets and spawned a movement that evolved in the face of ever-escalating violence to a revolution.